Pain-seq is a group of resources containing multi-omic data that we and our collaborators have published on our journey to improve our the understanding of and treatments for chronic pain and headache disorders

Contact us

William Renthal, M.D., Ph.D.,
Director of Headache Research, Brigham and Women’s Hospital,
Associate Professor of Neurology,
Harvard Medical School
wrenthal@bwh.harvard.edu

Shams Bhuiyan, Ph.D,
Research Fellow
Brigham and Women’s Hospital
Harvard Medical School
sbhuiyan1@bwh.harvard.edu

Renthal Lab
Harvard PRECISION Pain Center

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Harmonized cross-species DRG and TG atlases

Cell atlases for the dorsal root ganglion (DRG) and trigeminal ganglion (TG) across six species and 31 datasets including humans, non-human primates and rodents. This resource also includes a cell type nomenclature conversion tool to compare neuronal nomenclatures across multiple studies.

July 2024
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Nociceptor-immune interactome

An atlas of immune cells in three distinct inflammatory pain conditions and a database of their receptor-ligand neuroimmune interactions.

May 2024
ResourceArticle

Modeling Headache in Trigeminal Ganglion Cell Atlases

A cell atlas of human and mouse trigeminal ganglia that describes conserved and species-specific gene expression patterns and implicates multiple cell types in migraine pathophysiology.

March 2022
ResourceArticle

Sensory neuron subtypes in animal models of pain

A resource describing the transcriptional responses of distinct peripheral sensory neuron subtypes in animal models of pain (e.g. injury, inflammatory, chemotherapy-induced neuropathy) at single-nuclei resolution.

August 2020
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